Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO RE50096
SERIAL NO

17179720

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Abstract

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A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

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Patent Owner(s)

Patent OwnerAddress
NORTHEASTERN UNIVERSITYC/O THE CENTER FOR RESEARCH INNOVATION 360 HUNTINGTON AVENUE BOSTON MA 02115
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK35 STATE STREET ALBANY NY 12207-2826
TARGAGENIX INC25 HEALTH SCIENCES DRIVE STONY BROOK NY 11794

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amiji, Mansoor M Attleboro, US 26 1024
Botchkina, Galina Ivanovna Stony Brook, US 3 2
Egan, James E Stony Brook, US 14 83
Ojima, Iwao Port Jefferson, US 57 447

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