Use of known compounds as D-amino acid oxidase inhibitors

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United States of America Patent

PATENT NO RE49340
SERIAL NO

16401892

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Abstract

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The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.

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Patent OwnerAddress
NATIONAL YANG MING CHIAO TUNG UNIVERSITYNO 1001 DAXUE RD EAST DIST HSINCHU CITY 300

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hwu, Hai-Gwo Taipei, TW 6 1
Lai, Wen-Sung Taipei, TW 5 1
Liu, Chih-Min Taipei, TW 73 417
Liu, Yu-Li Miaoli County, TW 6 1
Sun, Chung-Ming Hsinchu, TW 18 87
Tseng, Yufeng Jane Stafford, US 9 4

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