Methods and compositions for treating malignant tumors associated with KRAS mutation
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United States of America Patent
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Oct 4, 2022
Grant Date -
N/A
app pub date -
Feb 28, 2020
filing date -
Feb 28, 2020
priority date (Note) -
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status (Latency Note)
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Abstract
This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-π.
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International Classification(s)
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- C07F:ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CO....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- C07D:HETEROCYCLIC COMPOUNDS
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- A61B:DIAGNOSIS; SURGERY; IDENTIFICATION
- 2020 Application Filing Year
- C07H Class
- 742 Applications Filed
- 387 Patents Issued To-Date
- 52.16 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- C07H Class
- 0 % this patent is cited more than
- 3 Age
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