Method of enhancing the effect of t-PA
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United States of America
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May 9, 1989
Grant Date -
N/A
app pub date -
Jun 26, 1987
filing date -
Aug 8, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
.[.The absorption rate of t-PA in the blood is enhanced by administering it together.]. .Iadd.A method of enhancing the effect of t-PA in the blood which comprises the steps of administering exogenous t-PA and an amount of t-PA inhibitor dissociating agent effective to increase the dissociation of the inhibitor from the t-PA, the amount of exogenous t-PA being less than that required to be administered in the absence of the inhibitor dissociating agent. The t-PA can be administered outside the blood when administered .Iaddend.with an absorption enhancing agent, preferably hydroxylamine or a salt thereof, most preferably hydroxylamine hydrochloride.Iadd., which constitutes both an enhancing agent and an inhibitor disassociating agent. .Iaddend.
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