Advanced microplate, microtiter, and microarray technologies with per-well fluidics, gas exchange, electronic sensors, and imaging for cell culture and other applications
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United States of America Patent
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Jun 12, 2018
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Mar 15, 2013
filing date -
Mar 15, 2013
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Abstract
Arrangements for per-well fluidics, gas exchange, and electronic sensors for microplate, microtiter, and microarray technologies are presented. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies. Cap arrangements can include or provide one or more sensors of various types, including but not limited to selective gas sensors, chemical sensors, temperature sensors, pH sensors, biosensors, immunosensors, molecular-imprint sensors, optical sensors, fluorescence sensors, bioFETS, etc. Incubator interfacing and imaging are also described. The invention can be used for living cell culture or other applications.
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