Expression vector system comprising two selection markers
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United States of America Patent
Stats
-
Jun 12, 2018
Issued Date -
N/A
app pub date -
Nov 21, 2016
filing date -
Feb 27, 2009
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention pertains to an expression vector or a combination of at least two expression vectors comprising at least
- (a) a polynucleotide encoding a product of interest or an insertion site for incorporating a polynucleotide encoding a product of interest;(b) a polynucleotide encoding a first selectable marker (sm I);(c) a polynucleotide encoding a second selectable marker (sm II), which is different from the first selectable marker (sm I),wherein the activity of the selectable marker (sm I) or (sm II) is at least partially influenced by the activity of the other selectable marker and wherein the selectable markers (sm I) and (sm II) are involved in the folate metabolism. Also provided are suitable host cells, selection methods and methods for producing polypeptides with high yield.
First Claim
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International Classification(s)
- 2016 Application Filing Year
- C12P Class
- 1834 Applications Filed
- 1256 Patents Issued To-Date
- 68.49 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 2 Citation Count
- C12P Class
- 56.21 % this patent is cited more than
- 7 Age
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