Reducing the immunogenicity of allografts

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United States of America Patent

PATENT NO 9994811
SERIAL NO

14879637

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Abstract

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There is provided an ex vivo method for reducing the immunogenicity of a tissue or organ prior to transplantation, comprising:

    (a) establishing the tissue or organ in a warm perfusion system capable of supporting oxidative metabolism of the tissue or organ;(b) perfusing the tissue or organ with a warm non-blood perfusion solution for at least 1 hour to allow passenger leukocytes within the tissue or organ to migrate from the tissue or organ into the recirculating perfusion solution;(c) isolating the passenger leukocytes from the recirculating perfusion solution to prevent the passenger leukocytes from re-entering the tissue or organ.

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Patent Owner(s)

Patent OwnerAddress
BRASILE LAURENNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brasile, Lauren Albany, US 20 1218

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