Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel

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United States of America Patent

PATENT NO 9993525
APP PUB NO 20140086874A1
SERIAL NO

14002070

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Abstract

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A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

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Patent Owner(s)

Patent OwnerAddress
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY845 SHERBROOKE STREET WEST MONTREAL H3A 2T5

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alessandrino, Antonio Como, IT 3 6
Barralet, Jake E Montreal, CA 5 47
Freddi, Giuliano Milan, IT 2 5
Marelli, Benedetto Montreal, CA 23 75
Nazhat, Showan N Montreal, CA 3 5

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