Resonance energy transfer assay with cleavage sequence and spacer
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United States of America Patent
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Jun 5, 2018
Issued Date -
Oct 5, 2017
app pub date -
Jun 12, 2017
filing date -
Sep 14, 2007
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Abstract
Methods for the identification of inhibitors of botulinum neurotoxins are described. Cells are provided that are genetically engineered to express peptides that act as a substrate for a botulinum neurotoxin and the provide reporting groups. Spacer sequences between the reporting groups serve to optimize energy transfer between the reporting groups. Characterization of the energy transfer-dependent signal prior to and following exposure to a botulinum neurotoxin in the presence of a candidate inhibitor provides a measure of the effectiveness of the candidate inhibitor.
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