Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
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United States of America Patent
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Jun 5, 2018
Issued Date -
Nov 3, 2016
app pub date -
Nov 30, 2015
filing date -
Nov 25, 2009
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Abstract
The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
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