Human and large-mammal lung bioreactor
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United States of America Patent
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Jun 5, 2018
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N/A
app pub date -
Jun 25, 2015
filing date -
Jan 8, 2013
priority date (Note) -
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Abstract
The present invention provides a bioreactor for large-mammal lung tissue. The bioreactor is capable of hydraulic driven negative-pressure and positive-pressure perfusion and ventilation. Perfusion and ventilation is delivered at physiological rates and is easily controllable. In one embodiment, the bioreactor comprises a support scaffold to support the size of a large-mammal lung tissue. In another embodiment, the bioreactor comprises a pleural sack that provides a small isolated fluid chamber which surrounds an engineered lung, thereby minimizing the amount of culture media needed. The present invention also provides an in vitro model for examining the function of a test agent and compositions and methods for alleviating a lung defect in a large-mammal.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- A01N:PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLA....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- C12M:APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- A61L:METHODS OR APPARATUS FOR STERILISING MATERIALS OR ....
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