Binding polypeptides having a mutated scaffold

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United States of America Patent

PATENT NO 9982022
SERIAL NO

14911319

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Abstract

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The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

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Patent Owner(s)

Patent OwnerAddress
AFFIBODY AB161 02 BROMMA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nilsson, Joakim Danderyd, SE 21 49
Nordling, Erik Danderyd, SE 15 41
Strömberg, Patrik Sollentuna, SE 9 44

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