Sustained release poloxamer containing pharmaceutical compositions
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United States of America Patent
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May 29, 2018
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app pub date -
Mar 2, 2016
filing date -
Feb 22, 2008
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Abstract
A thermo-reversible thermoplastic pharmaceutical composition, comprising a botulinum toxin and a biocompatible poloxamer which provides thermoreversibility to the composition and additionally stabilizes the botulinum toxin, is described. The pharmaceutical composition can be administered to a patient as a liquid, and gels after administration into a sustained release drug delivery system from which the biologically active botulinum toxin is released over a multi-day period thereby localizing the drug as a depot and controlling release to enhance the therapeutic effect per dose.
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