Method for purifying teriparatide
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United States of America Patent
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May 22, 2018
Issued Date -
N/A
app pub date -
Nov 11, 2015
filing date -
Nov 11, 2015
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention relates to a novel method for purifying teriparatide, a therapeutically active polypeptide fragment of full-length human parathyroid hormone. The method is based on ion exchange chromatography and is effective in separating the therapeutically active polypeptide from undesirable variants, such as truncated polypeptides. The method of the invention can be used at a preparative scale which allows it to be implemented into the production process for teriparatide. Accordingly, the invention also provides a method for the production of teriparatide which includes a step in which teriparatide is purified by the novel ion exchange chromatography method of the invention.
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|---|---|---|---|---|
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