Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues

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United States of America Patent

PATENT NO 9975932
APP PUB NO 20150140024A1
SERIAL NO

13522093

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Abstract

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The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.

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Patent OwnerAddress
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGFRANKFURTER STRASSE 250 DARMSTADT 64293

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cromwell, Oliver Suesel-Fassenberg, DE 31 52
Fiebig, Helmut Schwarzenbek, DE 30 50
Kahlert, Helga Hamburg, DE 9 10
Nandy, Andreas Hamburg, DE 18 27
Reese, Gerald Langen, DE 5 11
Wald, Martin Hamburg, DE 8 4
Weber, Bernhard Hamburg, DE 23 44

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