Inhibitors of HIV-1 entry and methods of use thereof
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United States of America Patent
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May 22, 2018
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app pub date -
Aug 13, 2015
filing date -
Aug 13, 2014
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Abstract
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.
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