Process for the preparation of ospemifene and fispemifene

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United States of America Patent

PATENT NO 9975832
APP PUB NO 20170342007A1
SERIAL NO

15539695

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Abstract

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Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CH2CH2—Y of formula 7, wherein X is a leaving group and Y is the —(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.

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Patent Owner(s)

Patent OwnerAddress
OLON S P ASTRADA RIVOLTANA KM 6/7 RODANO MI 20090

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alpegiani, Marco Rodano, IT 53 167
Cristiano, Tania Rodano, IT 6 0

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