Cell, method and kit for conducting an assay for neutralizing antibodies
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United States of America Patent
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May 15, 2018
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Mar 4, 2009
filing date -
Mar 4, 2008
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Abstract
The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., IFNα) that initiates a ligand-specific signal at the nucleus of the cell and for neutralizing antibodies against the extracellular ligand. The cell-based one-step assay allows both the extracellular ligand concentration and the neutralizing antibody titer to be quantified in a single sample (e.g., serum) without the need for sample dilution and addition of exogenous extracellular ligand.
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