Coupling method for peptide synthesis at elevated temperatures
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United States of America Patent
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May 15, 2018
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app pub date -
Jul 12, 2017
filing date -
Dec 19, 2014
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Abstract
An improved method for coupling amino acids into peptides or peptidomimetics is disclosed that includes the steps of combining an amino acid, a carbodiimide, an activator additive, and a base at less than 1 equivalent compared to the amino acid to be activated; and carrying out the activation and coupling at a temperature greater than 30° C.
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