Highly fluorogenic protein labelling agents
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United States of America Patent
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May 1, 2018
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app pub date -
Dec 14, 2016
filing date -
Dec 14, 2015
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Abstract
There are provided fluorogenic labelling agents comprising a dimaleimide core connected to a BODIPY-based fluorophore, processes for preparation thereof, and uses thereof for labelling and/or detection of specific protein targets. Fluorogenic labelling agents having an excitation wavelength that can be visualized in the green or red channels of fluorescence microscopes are provided. In some embodiments, fluorogenic labelling agents comprising a compound having the structure of Formula I or II, and salts thereof, are described.
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