Protein purification methods to reduce acidic species
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United States of America Patent
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May 1, 2018
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May 9, 2016
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Apr 20, 2012
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Abstract
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
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