3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
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United States of America Patent
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May 1, 2018
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Jun 15, 2017
app pub date -
Nov 10, 2016
filing date -
Jul 17, 2009
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Abstract
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
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