Glycerol 3-phosphate dehydrogenase for butanol production

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United States of America Patent

PATENT NO 9944954
APP PUB NO 20160376613A1
SERIAL NO

15228770

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Abstract

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Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.

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Patent OwnerAddress
GEVO INC345 INVERNESS DRIVE SOUTH BUILDING C SUITE 310 ENGLEWOOD CO 80112

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhalla, Ritu Tirmulgherry, IN 7 85
Chotani, Gopal K Palo Alto, US 50 567
Dauner, Michael Wilmington, US 23 439
Nelson, Mark J Newark, US 24 833
O'Keefe, Daniel P Ridley Park, US 33 333
Peres, Caroline M Palo Alto, US 31 389
Prasad, Jahnavi Chandra Wilmington, US 17 125
Tomb, Jean-Francois Wilmington, US 39 871

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