Enhanced purification of antibodies and antibody fragments by apatite chromatography
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United States of America Patent
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Apr 10, 2018
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Aug 5, 2015
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Jan 18, 2008
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Abstract
Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
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