Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents

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United States of America Patent

PATENT NO 9938316
SERIAL NO

14913366

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Abstract

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The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

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Patent Owner(s)

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YEDA RESEARCH AND DEVELOPMENT CO LTDWEIZMANN INSTITUTE OF SCIENCE P O BOX 95 REHOVOT 7610002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Karlish, Steven J D Rehovot, IL 3 11
Katz, Adriana Rehovot, IL 3 10
Marcovich, Arie Rehovot, IL 11 32
Tal, Daniel M Rehovot, IL 3 10

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