Abiraterone derivatives and non-covalent complexes with albumin
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United States of America Patent
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Apr 10, 2018
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Jun 26, 2015
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Jun 27, 2014
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Abstract
The present disclosure provides derivatives of abiraterone, non-covalently bound complexes of the abiraterone derivatives with serum albumin, pharmaceutical compositions of the same, and methods of use thereof. The non-covalently bound complexes are significantly more water-soluble than abiraterone and are useful for the treatment of a disease or condition that can benefit from CYP17 inhibition, such as prostate cancer.
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