Human neutralizing anti-kit antibodies and uses thereof

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United States of America Patent

PATENT NO 9932410
SERIAL NO

15034350

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Abstract

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The invention relates to human neutralizing anti-KIT antibodies and uses thereof. More particularly, the invention relates to an antibody comprising a heavy chain variable region comprising SEQ ID NO: 2 in the H-CDR1 region, SEQ ID NO: 3 in the H-CDR2 region and SEQ ID NO: 4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO: 7 in the L-CDR2 region and SEQ ID NO: 8 in the L-CDR3 region. The invention also relates to an antibody comprising a heavy chain variable region comprising SEQ ID NO: 10 in the H-CDR1 region, SEQ ID NO: 11 in the H-CDR2 region and SEQ ID NO: 12 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 14 in the L-CDR1 region, SEQ ID NO: 15 in the L-CDR2 region and SEQ ID NO: 16 in the L-CDR3 region.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)RUE MICHEL ANGE 3 75794 PARIS CEDEX 16 FRANCE
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)101 RUE DE TOLBIAC PARIS F-75013
ECOLE NORMALE SUPERIEURE DE CACHAN61 AVENUE DU PRESIDENT WILSON CACHAN 94230
UNIVERSITÉ DE MONTPELLIER34090 MONTPELLIER
INSTITUT REGIONAL DU CANCER DE MONTPELLIER208 RUE DES APOTHICAIRES F-34090 MONTPELLIER F-34090
UNIVERSITE PARIS - SUD15 RUE GEORGES CLEMENCEAU ORSAY 91400

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crepin, Ronan Cachan, FR 1 6
Le, Gall Mariane Montpelier, FR 1 6
Poul, Marie-Alix Montpelier, FR 5 24

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