Compositions and methods for immunomodulation in an organism
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United States of America Patent
Stats
-
Apr 3, 2018
Issued Date -
N/A
app pub date -
May 18, 2016
filing date -
May 17, 2005
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
First Claim
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International Classification(s)
Cited Art Landscape
Patent Citation Ranking
- 12 Citation Count
- A61K Class
- 94.91 % this patent is cited more than
- 7 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Oct 3, 2025 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Oct 3, 2029 |
