Doped materials for reverse phase chromatography
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Mar 27, 2018
Issued Date -
N/A
app pub date -
Mar 21, 2013
filing date -
Mar 28, 2012
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m2 to 0.8 μmol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (APIs) like peptides can be evaluated by (a) determining the isoelectric point (pI) of the API of interest, (b) choosing a pH in a range where the solid phase material is stable, (c) determining the difference pI−pH and (d) if the difference pI−pH is positive, choosing an anion exchange (AIEX) material, or if the difference pI−pH is negative, choosing an cation exchange (CIEX) material.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully