Compartmentalised combinatorial chemistry by microfluidic control

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United States of America Patent

PATENT NO 9925504
SERIAL NO

11643151

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Abstract

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The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahn, Keunho San Diego, US 43 4308
Bibette, Jerome Paris, FR 46 3113
Griffiths, Andrew Strasbourg, FR 44 4684
Link, Darren Guilford, US 21 3760
Weitz, David Cambridge, US 23 2442

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