2′/3′/5′-(R/S)-serinyl functionalized oligonucleotides
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United States of America Patent
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-
Mar 20, 2018
Issued Date -
N/A
app pub date -
May 2, 2014
filing date -
May 3, 2013
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2′ of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2′-O-[R/S-(2-amino-3-methoxy)propyl] nucleic acids with both ′3- and 5′-ends capped with two units of abasic serine have antisense activity against the miRNA.
First Claim
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International Classification(s)
- 2014 Application Filing Year
- C07H Class
- 1109 Applications Filed
- 1014 Patents Issued To-Date
- 91.44 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- C07H Class
- 0 % this patent is cited more than
- 7 Age
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