Spiro-oxazines, indolinones and preparation thereof
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United States of America Patent
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Mar 20, 2018
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Mar 3, 2017
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May 15, 2013
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Abstract
The present invention relates to novel spiro-oxazine analogs of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II Further the invention provides transition-metal free multicomponent reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile, under mild condition leading to formation of desired complex of spiro-oxazine analogs (I) and indolinone analogs (II) in high yield and selectivity.
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