Antibacterial agents: Nα-aroyl-N-aryl-phenylalaninamides
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United States of America Patent
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Mar 20, 2018
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app pub date -
Feb 6, 2015
filing date -
Feb 6, 2014
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Abstract
The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.
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