Targeting of interleukin-1 and -18 signaling in treatment of septic shock
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United States of America Patent
Stats
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Mar 20, 2018
Issued Date -
N/A
app pub date -
Jan 15, 2015
filing date -
Jan 21, 2014
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention relates to the inactivation of interleukin-1 and interleukin-18 signaling in treatment of inflammation and septic shock. More specifically, it relates to a sequential or simultaneous application of both an interleukin-1 receptor antagonist and an interleukin-18 antibody. In one preferred embodiment, a combination treatment of an IL-1 receptor antagonist and an IL-18 antibody is used.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
UNIVERSITEIT GENT | 9000 GENT | |
VIB VZW | GHENT |
International Classification(s)

- 2015 Application Filing Year
- A61K Class
- 16157 Applications Filed
- 11882 Patents Issued To-Date
- 73.55 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Cauwels, Anje | Merelbeke, BE | 15 | 60 |
# of filed Patents : 15 Total Citations : 60 | |||
Vandenabeele, Peter | Sint-Amandsberg, BE | 10 | 174 |
# of filed Patents : 10 Total Citations : 174 | |||
Vandenberghe, Tom | Haasdonk, BE | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 |
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Patent Citation Ranking
- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 20, 2025 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 20, 2029 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
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May 15, 2017 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Apr 16, 2017 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Apr 16, 2017 |
Apr 16, 2017 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Nov 25, 2016 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Apr 16, 2013 | I | Issuance | |
Aug 26, 2010 | P | Published | |
Mar 10, 2010 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GROS D'AILLON, ERIC;RUAT, MARIE;VERGER, LOICK;SIGNING DATES FROM 20100113 TO 20100301;REEL/FRAME:024058/0719 Owner name: COMMISSARIAT A L'ENERGIE ATOMIQUE, FRANCE |
Jan 20, 2010 | F | Filing | |
Feb 26, 2009 | PD | Priority Date |

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