Targeting of interleukin-1 and -18 signaling in treatment of septic shock

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United States of America Patent

PATENT NO 9919048
SERIAL NO

15111374

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to the inactivation of interleukin-1 and interleukin-18 signaling in treatment of inflammation and septic shock. More specifically, it relates to a sequential or simultaneous application of both an interleukin-1 receptor antagonist and an interleukin-18 antibody. In one preferred embodiment, a combination treatment of an IL-1 receptor antagonist and an IL-18 antibody is used.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITEIT GENT9000 GENT
VIB VZWGHENT

International Classification(s)

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  • 2015 Application Filing Year
  • A61K Class
  • 16157 Applications Filed
  • 11882 Patents Issued To-Date
  • 73.55 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cauwels, Anje Merelbeke, BE 15 60
Vandenabeele, Peter Sint-Amandsberg, BE 10 174
Vandenberghe, Tom Haasdonk, BE 1 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges92918022655157761477225301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000950010000

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