Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents
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United States of America Patent
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Mar 20, 2018
Grant Date -
Jun 23, 2016
app pub date -
Dec 23, 2015
filing date -
Dec 23, 2014
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Abstract
Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, and ART-838. The second agents include BCL-2 inhibitors such as ABT-199, ABT-263, and ABT-737; kinase inhibitors such as lestaurtinib, midostaurin, and sorafenib; and anti-neoplastic agents such as cytarabine, doxorubicin, etoposide, cyclophosphamide, triplotide, vinorelbine, cisplatin, and rituximab.
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