Enhanced DNA sensing via catalytic aggregation of gold nanoparticles by DNA hybridization chain reaction
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United States of America Patent
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Mar 13, 2018
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Mar 14, 2014
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Mar 15, 2013
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Abstract
The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.
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