G-rich isoDNA sequences forming G-quadruplex structure, their function as aptamers and a process for the preparation thereof
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United States of America Patent
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Mar 13, 2018
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May 23, 2014
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May 24, 2013
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Abstract
The present invention relates to G-quadruplex forming isoDNA aptamers and a process for the preparation thereof. The present invention further relates to a stable, non-genetic, guanine rich 2′-5′ linked isoDNA selected from 3′ deoxy 2′-5′ isoDNA and 3′ deoxy 2′-5′ isoDNA-isoRNA hybrid. The instant 2′-5′ linked isoDNA such as the thrombin binding aptamer (isoTBA) can be used in deep vein thrombosis, where prolonged anticoagulant activity is required.
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