Method for making heteromultimeric molecules
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United States of America Patent
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Mar 13, 2018
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Mar 3, 2016
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Apr 27, 2009
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Abstract
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
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