Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same

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United States of America Patent

PATENT NO 9913885
APP PUB NO 20160361403A1
SERIAL NO

15207271

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Abstract

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Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.

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Patent Owner(s)

Patent OwnerAddress
INOVIO PHARMACEUTICALS INC660 W GERMANTOWN PIKE SUITE 110 PLYMOUTH MEETING PA 19462

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ferraro, Bernadette La Jolla, US 25 26
Ramanathan, Mathura P Ardmore, US 16 40
Sardesai, Niranjan Y Blue Bell, US 30 172
Weiner, David Merion, US 142 723
Yan, Jian Wallingford, US 159 443

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