Methods and compositions for reducing the proliferation of gram positive bacteria
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United States of America Patent
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Mar 13, 2018
Grant Date -
Mar 26, 2015
app pub date -
Mar 14, 2013
filing date -
Mar 28, 2012
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Abstract
Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are compositions containing a dye (e.g., an azo dye) and a TarO inhibitor, and kits containing at least one of these compositions.
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