Genetically modified mouse whose genome comprises a humanized CD274 gene
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United States of America Patent
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Mar 13, 2018
Grant Date -
Jun 9, 2016
app pub date -
Dec 9, 2015
filing date -
Dec 9, 2014
priority date (Note) -
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status (Latency Note)
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Abstract
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
First Claim
Other Claims data not available
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| Country | kind | publication No. | Filing Date | Type | Sub-Type |
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International Classification(s)
- 2015 Application Filing Year
- A61K Class
- 16157 Applications Filed
- 11882 Patents Issued To-Date
- 73.55 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 2 Citation Count
- A61K Class
- 50.93 % this patent is cited more than
- 7 Age
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