Label-free detection of small and large molecule interactions, and activities in biological systems
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United States of America Patent
Stats
-
Mar 6, 2018
Issued Date -
N/A
app pub date -
Dec 14, 2015
filing date -
Dec 15, 2014
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A system for quantitative detection and analysis of the interactions of molecules with molecular receptors on the surfaces of biological cells based on detecting a mechanical deformation in the membrane of a cell associated with the molecular interactions, which works for both large and small molecules. The mechanical deformation can be detected with high precision in real time from an optical image of the cell with a differential detection method. The system can be also used to detect the electrical activities, such as ion channel opening and closing, as well as action potential propagation in neuronal cells.
First Claim
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International Classification(s)
- 2015 Application Filing Year
- G01N Class
- 11310 Applications Filed
- 8345 Patents Issued To-Date
- 73.79 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 9 Citation Count
- G01N Class
- 40.30 % this patent is cited more than
- 7 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 6, 2025 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 6, 2029 |
