Composition and methods for highly efficient gene transfer using AAV capsid variants
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United States of America Patent
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Mar 6, 2018
Issued Date -
Mar 5, 2015
app pub date -
Apr 18, 2013
filing date -
Apr 18, 2012
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Abstract
Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial transgenes. AAV variants are provided which exhibit increased transduction efficiency when compared to AAV serotypes (e.g., AAV1, AAV2, AAV8, AAV-rh74), which lack the modifications disclosed herein. Such improved vectors are useful for transduction of a variety of tissues.
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