Single domain antibodies capable of modulating BACE activity

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United States of America Patent

PATENT NO 9908943
SERIAL NO

14023586

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Abstract

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Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
VRIJE UNIVERSITEIT BRUSSELLAARBEEKLAAN 103 BRUSSEL 1090
KATHOLIEKE UNIVERSITEIT LEUVEN K U LEUVEN R&DMINDERBROEDERSSTRAAT 8A - BOX 5105 LEUVEN B-3000
VIB VZWRIJVISSCHESTRAAT 120 9052 GENT BELGIUM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Strooper Bart Leuven, BE 15 37
Marjaux, Els Attenrode-Wever, BE 3 14
Muyldermans, Serge Hoeilaart, BE 22 212
Zhou, Lujia Leuven, BE 6 25

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