Imidamide sphingosine kinase inhibitors
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United States of America Patent
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Mar 6, 2018
Issued Date -
N/A
app pub date -
Aug 19, 2016
filing date -
Aug 14, 2009
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Abstract
Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 722 PRESTON AVENUE SUITE 107 CHARLOTTESVILLE VA 22903 |
International Classification(s)

- 2016 Application Filing Year
- A61K Class
- 19101 Applications Filed
- 13019 Patents Issued To-Date
- 68.16 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Kennedy, Andrew | Charlottesville, US | 59 | 431 |
# of filed Patents : 59 Total Citations : 431 | |||
Kharel, Yugesh | Charlottesville, US | 7 | 9 |
# of filed Patents : 7 Total Citations : 9 | |||
Lynch, Kevin R | Charlottesville, US | 42 | 346 |
# of filed Patents : 42 Total Citations : 346 | |||
Macdonald, Timothy L | Charlottesville, US | 62 | 680 |
# of filed Patents : 62 Total Citations : 680 | |||
Mathews, Thomas P | Charlottesville, US | 6 | 29 |
# of filed Patents : 6 Total Citations : 29 |
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- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 6, 2025 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 6, 2029 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text
US Patent No: 9120109
Nozzle insert device and methods for dispensing head atomizer
Abstract
A dispensing head for emitting an atomized spray of liquid droplets includes an actuator and a nozzle insert. The actuator includes a gas duct and a liquid duct and may be attached to a container housing a propellant gas and a liquid product. The nozzle insert includes at least one modular structure that can be installed in an actuator socket on the actuator. The nozzle insert includes a pressure cap defining a pressure chamber having an exit orifice. A liquid conduit is disposed in the pressure chamber and defines a liquid supply channel having a liquid supply channel exit opening. The nozzle insert is configured to form a reflux cell in the liquid supply channel upstream of the liquid supply channel exit opening to achieve flow blurring interaction between the liquid product and the gas propellant.
Description
Claims
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Legal Events
Date | Code | Event | Description |
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Jan 18, 2023 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 8TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2552); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 8 |
Mar 27, 2019 | FEPP | FEE PAYMENT PROCEDURE | free format text: SURCHARGE FOR LATE PAYMENT, SMALL ENTITY (ORIGINAL EVENT CODE: M2554); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
Mar 27, 2019 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 4 |
Mar 01, 2019 | AS | ASSIGNMENT | free format text: SECURITY INTEREST;ASSIGNOR:ZYXOGEN, LLC;REEL/FRAME:048505/0123 Owner name: SIRROM PARTNERS, L.P., TENNESSEE Effective Date: Mar 01, 2019 |
Sep 01, 2015 | I | Issuance | |
Aug 12, 2015 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
Aug 29, 2013 | P | Published | |
Apr 20, 2012 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ZYXOGEN, LLC;REEL/FRAME:033611/0188 Owner name: UNIVERSIDAD DE SEVILLA, SPAIN Effective Date: Mar 20, 2014 free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GANAN-CALVO, ALFONSO M.;ASENSIO-CANO, MIGUEL A.;FIT0-PLANAS, ALVARO;AND OTHERS;REEL/FRAME:033611/0387 Owner name: UNIVERSIDAD DE SEVILLA, SPAIN Effective Date: Mar 27, 2014 free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BADOVICK, JEFFREY;REEL/FRAME:033611/0082 Owner name: ZYXOGEN, LLC, TENNESSEE Effective Date: Apr 20, 2012 |
Feb 29, 2012 | F | Filing |

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