Stabilized mutant opsin proteins

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United States of America Patent

PATENT NO 9907762
SERIAL NO

14845761

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Abstract

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Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF WASHINGTONSEATTLE WA 98105-4721

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  • 2015 Application Filing Year
  • A61K Class
  • 16157 Applications Filed
  • 11882 Patents Issued To-Date
  • 73.55 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kaushal, Shalesh Gainesville, US 16 238
Kuksa, Vladimir Seattle, US 5 69
Noorwez, Syed M Gainesville, US 6 82
Palczewski, Krzysztof Bellevue, US 64 842

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