Contribution of oxidative stress to AF electrograms
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United States of America Patent
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Mar 6, 2018
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Mar 9, 2017
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Feb 1, 2013
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Abstract
The invention relates generally to methods of detecting reactive oxygen species (ROS) in cardiac tissue and treatment modalities for ablating ROS-associated tissue in cardiac disease. The methods rely upon targeting ROS-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded atrial EGMs for a tissue to assess ROS content and underlying AF organization as a function of ROS blockade conditions.
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