Method for generation of regulatory T-cells using factors secreted by iNKT cells

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United States of America Patent

PATENT NO 9902935
SERIAL NO

14763002

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Abstract

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The current invention concerns the use of PIP or S100A8 for the generation of regulatory T cells. The current invention provides a method of generating regulatory T cells by contacting immature DC with PIP or S100A8 to produce tolerogenic DC and further contacting naïve T cells to the tolerogenic DC to produce regulatory T cells. The invention also concerns PIP protein where immature DC contacted with PIP produce tolerogenic DC that induce conversion of naïve T-cells into regulatory T cells. The invention also concerns S100A8 protein where immature DC contacted with S100A8 produce tolerogenic DC that induce conversion of naïve T-cells into regulatory T cells. The invention also provides methods for identification of factors secreted by iNKT cells that induce conversion of immature DC into tolerogenic DC. The subject invention also concerns using regulatory T cells for treatment and/or management of cancer or the diseases of the immune system.

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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED223 GRINTER HALL GAINESVILLE FL 32611

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  • 2014 Application Filing Year
  • A61K Class
  • 14144 Applications Filed
  • 11600 Patents Issued To-Date
  • 82.02 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, Hyeong Woo Gainesville, US 1 0
Wilson, Brian Samuel Gainesville, US 1 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges92918022655157761477225301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000950010000

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