Synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes
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United States of America Patent
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Feb 27, 2018
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Oct 24, 2012
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Oct 24, 2012
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Abstract
A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.
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