Mass spectrometry analysis of biomolecules by multiple charge state selection using a concurrent precursor isolation technique
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United States of America Patent
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Feb 20, 2018
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Jun 3, 2016
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Jun 3, 2016
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Abstract
A method is described for the analysis of biological polymers, for example, intact proteins or oligonucleotides, by mass spectrometry. This method produces sample ions from a sample containing biological polymers, and ion species are selected that correspond to different charge states of a biological polymer molecule. The ion species are concurrently isolated from the sample ions to generate precursor ions in an ion trap mass spectrometer or in a quadrupole mass filter mass spectrometer. Precursor ions or product ions derived from the precursor ions may then be mass analyzed. The mass analysis step may include fragmenting the precursor ions to form product ions.
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